Another PEG-based sealant paper raises questions of efficacy in aerostasis

In a recently published article relating to the use of PEG-based sealant Coseal (, the authors conclude that use of the product was associated with a longer time to cessation of air leak, longer time to drain removal (4 vs 3 days) and a longer length of stay (7 vs 6 days). This follows the recent withdrawal of Covidien’s Pleuraseal (also PEG-based) following reportedly poor clinical performance. In contrast Tissuemed’s post-marketing study, supplemented by further data collected since the study, suggests that use of TissuePatch3 and its sister product TissuePatchThoracic provides instant intraoperative air leak treatment with sustained effect, reduced drain time and potential to modify the patient treatment algorithm to reduce patient stay. Tissuemed is working to substantiate these findings and provide statistical significance with larger prospective study including digital air leak monitoring, but anecdotally is receiving significant positive feedback on all important criteria.