Clinical Findings

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Neuro/Spine

Peer-reviewed Journal Publications

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A purely synthetic and biodegradable material for repair of cerebrospinal fluid rhinorrhoea

Surda, P., Syed, I., Modayil, P.C., Little, S.A. & Toma, A

Department of Otolaryngology, St Georges’ Hospital, London, UK

Surgeons at St Georges’ Hospital London, led by Dr Abbad Toma have published findings from a series of patients where TissuePatchDural™ was used to successfully treat cerebrospinal fluid rhinorrhoea – CSF leaks through the nasal cavity.

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Two alternative dural sealing techniques in posterior fossa surgery

Schiariti M, Acerbi F, Broggi M, Tringali G, Raggi A, Broggi G, Ferroli P

Carlo Besta Institute, Milan, ITALY

Published in Surgical Neurology International. Two alternative dural sealing techniques in posterior fossa surgery: (Polylactide‑co‑glycolide) self‑adhesive resorbable membrane versus polyethylene glycol hydrogel.

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Preliminary retrospective study on 119 consecutive high-risk patients.

Ferroli P, Acerbi F, Broggi M, Schiariti M, Albanese E, Tringali G, Franzini A, Broggi G

Carlo Besta Institute, Milan, ITALY

This first publication from the world-renowned Carlo Besta Institute presents their impressive experience using TissuePatchDural™ for achieving dural closure in a series of 119 high risk patients.

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Intraoperative sealing of dura mater defects with a novel, synthetic, self adhesive patch

von der Brelie C, Soehle M, Clusmann HR

University of Bonn, GERMANY

A single centre series in 25 patients presenting excellent product safety with follow-up for 12 months.

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Use of a new absorbable sealing film for preventing postoperative cerebrospinal fluid leaks

Della Puppa A, Rossetto M, Scienza R

University of Padova, ITALY

Published in the British Journal of Neurosurgery in 2010, neurosurgeons detailed the first clinical experience with TissuePatch for dural closure. 100% watertight closure was achieved with patients followed for up to 9 months.

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Posters/Presentations

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Use of Surgical Sealant Films to Reduce Hospital Stay after Video-Assisted Thoracoscopic Lung Volume Reduction

Bilancia R, Oey I, Sharkey A, Bertoglio P, Perikleous P, Tenconi S, Waller D

Glenfield Hospital, Leicester, UK

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A single centre experience with two surgical sealants for CSF leak prevention in Posterior Fossa surgery

Palin MS, van Hille P

Department of Neurosurgery, Leeds General Infirmary, UK

To review the safety and efficacy of a new sealant film for adjunctive closure of the dura mater in a series of patients undergoing posterior fossa surgery.

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Cerebrospinal Fluid Rhinorrhea: Preventive Strategy in Transnasalsphenoidal Surgery

Berlucchi S, Gerunda A, Scanarini M

Operating Unit, Endocrine Neurosurgery, University Hospital of Padua

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Avoidance of CSF leak after Microvascular Decompression with Clinical Use of a New Synthetic Adhesive Film

Ferroli P, Angius D, Acerbi F, Tringali G, Broggi M, Broggi G, Franzini A

Carlo Besta Institute, Milan, ITALY

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Dural Reconstruction in Surgery of the Posterior Cranial Fossa

Nuzzi D, Masotto B, Ricci UM, Turazzi S

Department of Neurosurgery at the Integrated University Hospital, Verona

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Intraoperative sealing of dura mater defects with a new, purely synthetic, self adhesive patch – an application study

von der Brelie C., Clusmann H.

Neurosurgical Department ; University of Bonn Medical Center

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White Papers

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Use of Lyomesh augmented with TissuePatchDural for repair of dural defect in spinal cord herniation.

Ivanov, M

Sheffield Teaching Hospitals, UK

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Use of Pre-soaked TissuePatchDural for Dural closure following surgery for Low Grade Glioma

Goodden J

Leeds General Infirmary, Leeds, UK

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Use of TissuePatchDural for Dural closure for Revision Craniotomy

Goodden J

Leeds General Infirmary, Leeds, UK

TissuePatchDural™ used for original dural closure

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Use of TissuePatchDural for closure of a midline Spinal Durotomy following removal of an Intradural Schwannoma

Scott A. Rutherford

Dept. Of Neurosurgery, Salford Royal Hospital, Manchester, UK

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Use of TissuePatchDural for Dura sealing in a patient with recurrent high grade Glioma.

Christian von der Brelie, MD

Dept. of Neurosurgery, University of Bonn, Germany

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Radiological follow-up after use of TissuePatchDural for closure of the Dura following resective brain surgery

Christian von der Brelie, MD

Dept. Of Neurosurgery, University of Bonn, Germany. Department of Neurosurgery, Tygerberg Hospital, South Africa

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Use of TissuePatchDural as an adjunct to sutured closure of the dura following excision of lumbar intradural tumour

Ryan Waters Ali Nader-Sepahi

Wessex Neurological Centre, Southampton

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Use of TissuePatchDural to repair a Posterior semicircular Canal Perilymph Fistula

Peter A Rea, Esmond Carr

The Leicester Balance Centre and Leicester Royal Infirmary

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Use of TissuePatchDural for closure of the Dura following removal of a Colloid Cyst

John Goodden

Leeds General Infirmary, Leeds, UK

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Clinical and radiological follow up after use of TissuePatchDural for closure of the Dura following resection of cavernous haemangioma of the brainstem

Christian von der Brelie, MD Hans Clusmann, MD

Dept. Of Neurosurgery, University of Bonn, Germany

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Use of TissuePatchDura as an adjunct to sutured closure of the Dura following Craniectomy

Pablo Goetz, Kevin O’Neill

Dept. Of Neurosurgery, Charing Cross Hospital, London

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Use of TissuePatchDural for sealing of the Dura following Amygdalohippocampectomy.

Christian von der Brelie, MD Hans Clusmann, MD

Dept. of Neurosurgery, University of Bonn, Germany

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Use of TissuePatchDural for closure of the Dura following Parietal Craniotomy and insertion of Gliadel wafers

David Mandley PhD

Tissuemed Ltd.

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Use of TissuePatchDural in a Porcine Dural Repair Model

David Mandley PhD

Tissuemed Ltd.

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