TissuePatch: It’s a Tissue Sealant not a Tissue SubstituteMarch 17, 2011
On first encountering TissuePatch in any of its iterations it is tempting to think of it as some form of tissue substitute…after all it is a solid sheet of synthetic material with no obvious adhesive quality to the touch, and it certainly does not bear any resemblance to the traditional and relatively commonplace liquid sealants. At Tissuemed we go to great lengths to make sure our distributing partners understand the indications for use for our product and moreover the limitations to its use. As a firmly adherent film (to proteins on tissue surfaces) it is in many ways the perfect sealant, adjunctive to traditional closure techniques. However by the same token it is definitely not a tissue substitute because it is not designed to be. It is not a scaffold and does not have a structure likely to be a substrate for tissue ingrowth. Surgeons develop their own armoury of products, and often the lines between indications get blurred….dural substitutes get used as sealants, haemostats get used as sealants, sealants get used as haemostats, external wound closure cyanoacrylate glues have even been known to find their way into internal tissue closure. So to clarify the take-home messages for TissuePatch are:
Will it act as a haemostat?…..only by virtue of bonding to tissues, so physical rather than thrombogenic.
Will it prevent adhesions?….it will separate tissues, but we don’t have evidence to support an anti-PSA claim. At least it doesn’t appear to be adhesiogenic and we have good evidence of this from 2nd look surgery.
Will it act as a tissue scaffold/substitute?….no
Is it an incredibly effective sealant?….yes
Hope that helps